The regulatory factor SipA is a highly stable β-II class protein with a SH3 fold

Is the novel amyloid-β tetramer fold a stable conformation?

In the pathogenesis of Alzheimer’s disease (AD), the most common neurodegenerative disorder, the amyloidb (Ab) peptide plays a key role. Originally, the Ab fibrils were postulated to be the neurotoxic agents for a long time, because an increased presence of extracellular amyloid plaques, composed primarily of insoluble Ab fibrils, is found in the brain of affected patients. Recent studies, howe...

A Highly Diastereoselective and Enantioselective Phase-Transfer Catalyzed Epoxidation of β-Trifluoromethyl-β,β-disubstituted Enones with H2O2

Trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.An efficient epoxidation of β-CF3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and F5-substituted chiral qua...

An engineered class I transfer RNA with a class II tertiary fold.

Structure-based engineering of the tertiary fold of Escherichia coli tRNA(Gln)2 has enabled conversion of this transfer RNA to a class II structure while retaining recognition properties of a class I glutamine tRNA. The new tRNA possesses the 20-nt variable stem-loop of Thermus thermophilus tRNA(Ser). Enlargement of the D-loop appears essential to maintaining a stable tertiary structure in this...

IFN- -Induced MHC Class II Expression: Transactivation of Class II Transactivator Promoter IV by IFN Regulatory Factor-1 is Regulated by Protein Kinase

Multi-class Protein Fold Recognition Through a Symbolic-Statistical Framework

Protein fold recognition is an important problem in molecular biology. Machine learning symbolic approaches have been applied to automatically discover local structural signatures and relate these to the concept of fold in SCOP. However, most of these methods cannot handle uncertainty being therefore not able to solve multiple prediction problems. In this paper we present an application of the ...